IVF In Vitro Fertilisation

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BACKGROUND

The first baby born as a result of in vitro fertilisation dates back to 1978. Since then, IVF has developed into a treatment accepted for infertility worldwide. It is estimated that five million IVF babies have been born.

In short, IVF is the process of fertilisation that takes place in a laboratory instead of in the fallopian tube. Laboratory techniques play a central role in the success of the fertilisation and embryo development. The body conditions are mimicked, as far as possible, with new scientific developments in the field every year to improve these conditions.

In contrast to popular belief, the fertilisation process itself in IVF is not artificial or ‘conducted via man’. IVF is only the process of bringing the sperm and eggs together. The process must then take its physiological and biological course.

ENSURING OPTIMAL EMBRYO DEVELOPMENT

EmbryoScope™ is the world’s most used time-lapse system for observation of embryo development, while maintaining stable embryo culture conditions. It has been used in more than 300.000 patient treatments since 2009.

At the heart of the system is the EmbryoScope™ incubator which ensures stable incubation while automatically taking images of the developing embryos at defined intervals. This information is transferred to the ES server so that the information can be accessed from conveniently accessed computer stations.


How it Works

Even in ICSI, the sperm are merely selected on ‘looks’ or morphology, and the genetics and internal biology are not available to choose between, for example, eye colour or boy and girl sperm.

Woman Organ
  1. The woman is given hormone treatment to stimulate egg production.
  2. Multiple eggs are taken from the woman’s ovaries.
  3. In the lab, the eggs are mixed with the sperm cells to become fertilized.
  4. The fertilized eggs, or embryos, are placed in an incubator for about 48 hours.
  5. Embryos are implanted in the woman’s uterus or frozen for future implanting.

Usually, only about 60 to 70% of eggs will fertilise, and 40 to 60% of the fertilised eggs may not make it to day 5 stage embryos. Only 5 to 7% of eggs may result in a live born baby.

Embryos are cultured for up to seven days in the laboratory, where the best or highest quality ones are chosen for transfer or freezing. The estimation of embryo quality is a discretionary process via a highly-skilled, trained eye of an embryologist. The quality of embryos correlates with the chances of success – an embryo that can implant and a resulting pregnancy. The other half of the coin is also important – the uterus lining or endometrium, which is actually much more difficult to assess.

Indications for IVF

  • • Tubal Factors
  • • Mild Sperm Factor or Normal Sperm Parameters
  • • Unexplained Infertility – Normal Ovulatory Cycles and Normal Sperm Parameters
  • • Recurrent Miscarriages
  • • Erectile Dysfunction
  • • Polycystic Ovaries

ICSI

Intra-Cytoplasmic Sperm Injection

ICSI was introduced in the early 1990s and has changed many couples’ chances of successful fertilisation.

ICSI takes IVF a step further and introduces a single selected sperm to the inside of the egg. It therefore
crosses a barrier that some sperm or eggs cannot do on their own. ICSI requires highly skilled embryologists
to apply the required micromanipulation technique. It uses specialised equipment and micro-needles to handle
the sperm and the eggs.

Indications For ICSI

  • • Failed IVF Fertilisation
  • • Poor Sperm Parameters
  • • Sperm Extracted from the Testis
  • • Low Oocyte Count
  • • Spinal Injury in Men
  • • Women Older than 38

What is the EmbryoScope™?

In standard IVF the embryos are removed from the incubator every second day so embryologists can make sure they’re growing as they should be. The EmbryoScope™ is an IVF incubator with a built-in camera for automated imaging of the oocytes in a closed incubation environment from fertilization until the time of the embryo transfer.
It is a system that is an incubator, a microscope with an integrated camera and advanced software at the same time. The EmbryoScope™ time-lapse system provides superior image quality, thereby allowing the embryologist to visually follow the development of the embryos. In this way, the embryologist can distinguish and choose between normal developing embryos with good implantation potential and development patterns with a risk of implantation failure.


All of Our services

We will be there every step of the way, offering advice and support. From determining the possible cause of infertility, to explaining and recommending the most suited assisted conception\methods for you / you and your partner.

AI/ IUI

AI/ IUI

Artificial Insemination/Intra-Uterine Insemination

This procedure consists of a combination of superovulation (stimulating the growth of more than one egg) with insemination of the prepared sperm sample at the time of ovulation.

IVF

IVF

In Vitro Fertilisation

IVF is the process of fertilisation that takes place in a laboratory instead of in the fallopian tube. Laboratory techniques play a central role in the success of the fertilisation and embryo development.

ICSI

ICSI

Intra-Cytoplasmic Sperm Injection

ICSI takes IVF a step further and introduces a single selected sperm to the inside of the egg. It has changed many couples’ chances of successful fertilisation.

IMSI

IMSI

Intracytoplasmic Morphologically-selected Sperm Injection

IMSI is an advanced method over ICSI to improve embryo quality. IMSI has been shown to improve embryo quality, reduce miscarriages rate, and increase chances of an ongoing pregnancy.

Egg Freezing

Egg Freezing

Egg Freezing is a smart solution that’s highly recommended for women looking to postpone starting a family, for whatever reason.

Assisted Hatching

Assisted Hatching

A technique carefully applied to the embryo by the embryologist with specialised equipment or mediums to help the embryo escape from the zona more readily (often used on frozen embryos and for older women, 38+).

Meet The Team

Meet the proud Founders of Wijnland Fertility - Dr Johannes and Lizanne van Waart - as well as the rest of the team, including Associated Clinicians, Embryologists, Infertility Sisters and Psychologists. Find out more and view the videos.

Wijnland Fertility is indeed one of the leading IVF clinics in
South Africa; the results and the patient care are outstanding.

- Prof Cecilia Sjoblom, Sydney 2013, 2014
ASSISTED HATCHING

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